I've heard that Zbrush doesn't allow you to shrink whole rows of vertices accurately down to points, which would limit the kinds of things you can do. Making a single sculptie look like multiple prims, for instance, requires that you collapse certain vertex rows into points.
If Zbrush does in fact have this limitation, I would not recommend it.
As for Blender and sculpties, this appears to be a decent tutorial:
Sculpt Blend - Second Life Sculptie Tutorials
Oh, and if you're using
Blender: Noob to Pro, stop. It's rubbish. Blender's UI is nightmarish enough without bad, hodgepodge wiki tutorials making it harder.