I can't get with the blender interface. If you are used to Photoshop I think that Zbrush is the most intuitive interface with the lowest learning curve, only draw back is it is hard to make hard lines imo in ZBrush but you can do great things for clothing and organic sculpts in ZBrush.
The videos at Shiny Life will show you step by step the techniques you need to know to get started in Zbrush. If you can work with clay you can make sculpts in Zbrush.
Shiny Life » Videos